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Designer Microbes and the Future of Industrial Biotechnology
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== <span style="color: #FFFFFF;">Remembering</span> == * '''Designer Microbe''' β "A Microorganism" "Whose Genome" has been "Substantially Modified" or "Partially Synthesized" to "Give It" "New" "Metabolic Capabilities." * '''Metabolic Engineering''' β "The Targeted" "Modification" of "An Organism's Metabolism" to "Increase" "Production" of "A Desired Compound." * '''Synthetic Biology''' β (See Article 692). "The Application" of "Engineering Principles" to "Biology": "Designing" "Biological Systems" like "Circuits" and "Devices." * '''Genetic Circuit''' β "A Network" of "Genes" "Designed" to "Respond" to "Specific" "Input Signals" and "Produce" "Desired" "Outputs" (like an "Electronic" "Logic Gate"). * '''Minimal Genome''' β "The Smallest" "Set" of "Genes" "Sufficient" for "A Cell" to "Survive." (JCVI Syn3.0: 473 genes). "The Starting Point" for "Designer Organisms." * '''Artemisinin''' β "A Malaria Drug" previously "Sourced Only" from "A Rare Plant" β "Now Produced" by **"Engineered Yeast"** at "Industrial Scale" (Jay Keasling, UC Berkeley). * '''Spider Silk from Bacteria''' β "A Material" "Stronger than Steel" β "Now Produced" by "Bacteria" "Given" the "Spider Silk Gene." * '''Cell-Free Synthesis''' β "Performing" "Biological" "Synthesis Reactions" with "Cell Extracts" (Ribosomes, Enzymes) "Without" "A Living Cell" β "Faster" and "More Controllable." * '''The iGEM Registry''' β (International Genetically Engineered Machine). "A Public" "Library" of **"Standard" "Biological Parts"** (BioBricks) for "Building" "Genetic Circuits." * '''Biosafety Level''' β "A Classification" of "Containment Precautions" required for "Work" with "Biological Agents": **"Critical"** for "Designer Microbe" "Research." </div> <div style="background-color: #006400; color: #FFFFFF; padding: 20px; border-radius: 8px; margin-bottom: 15px;">
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